The Role of VDR Gene Polymorphisms in Vitamin D Supplementation

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The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signals are involved in various biological processes, including calcium and phosphorous metabolic processes parathormone release, cell growth and regulation of innate and adaptive immunity.

A T > C base change in the promoter region of the VDR variant rs11568820 obliterates the binding site for the transcription factor Cdx2 upstream of exon 1e. This results to the production of a smaller protein that has reduced transcriptional activity. The F allele of this variant can be found at a high frequency in Asians and Europeans and at a lower frequency in Sub-Saharan Africa.

The results of this study advance our understanding of the role that VDR gene polymorphisms can play in modulating the response to diet supplementation with calcium www.oldetowntimes.net/a-great-hack-for-the-nintendo-wii/ calcitriol. Carriers of the TaqI and FF genotypes of the FokI polymorphisms exhibit higher transcriptional activation and are associated with higher calcium absorption, higher bone mineral density, and a decreased risk of fractures. To increase our understanding of the role these genetic variations play in vitamin D supplementation, we need to conduct more research using a homogeneous design.